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Project 10463: CRYPTON - A genome-based generalized strategy to activate crypticantibiotic biosynthesis gene clusters in Actinomycetales

Projectleader: Dr. Eriko Takano

Emerging resistant bacteria have created an urgent need for new antibiotics. Inspection of genome sequences from several antibiotic producing organisms reveals numerous novel antibiotic biosynthetic clusters that are not expressed under typical conditions and have the potential to produce a novel metabolite, often with possible antibacterial activity. We aim to identify these cryptic antibiotic biosynthesis clusters from genome sequences of commercially relevant microbes (Actinomycetales and related rare actinomycetes), which will be provided by our company collaborators DSM and Ktedogen. We will use state-of-the-art bioinformatics analysis, semi-synthetic activation methods, and novel screening methods to produce and identify the new antibacterial compounds.

People involved

Dr. E. Takano
Project function: Main applicant and project leader
Organisation: University of Groningen

Dr. R. Breitling
Project function: Fellow applicant
Organisation: University of Groningen

Prof. dr. C.M.J.E. Vandenbroucke-Grauls
Project function: Fellow applicant
Organisation: VU Medical Center Amsterdam

Dr. A. Kovalchuk
Project function: Post Doc
Organisation: University of Groningen

M.A. Medema
Project function: PhD student
Organisation: University of Groningen

Contact information

Dr. E. Takano
Rijksuniversiteit Groningen
Faculteit Wiskunde en Natuurwetenschappen
Microbiële Fysiologie
Postbus 14

T: 050-363 21 43
F: 050-363 21 54
E: e<dot>takano<at>rug<dot>nl