Project leader: Prof. dr. Gilles van Wezel
As the largest source of antibiotics, the filamentous soil bacteria of the family of actinomycetes are exceptional industrial microorganisms, and a major asset in combating multiple drug-resistant pathogens. The GenExpand project aims to identify antibiotics that have so far gone unnoticed, by combining full genome sequencing to identify hidden antibiotic clusters with the development of bioessays and chemical tweezers for the idenitification of specific classes of natural products. Within the project lantibiotics are a focal point. At the same time GenExpand will form a broad-impact benchmark for future antibiotic research by augmenting the available genome sequences of antibiotic-producing actinomycetes and by offering new technologies for compound identification
People involved
Prof. dr. G.P. van Wezel
Project function: Main applicant and project leader
Organisation: Leiden University
Prof. dr. A. van Belkum
Project function: Fellow applicant
Organisation: ERasmus MC Rotterdam
Dr. Y.H. Choi
Project function: Fellow applicant
Organisation: Leiden University
Dr. ing. M.O.M. Overhand
Project function: Fellow applicant
Organisation: Leiden University
Prof. dr. H.S. Overkleeft
Project function: Fellow applicant
Organisation: Leiden University
Prof. dr. R. Verpoorte
Project function: Fellow applicant
Organisation: Leiden University
Dr. E. Vijgenboom
Project function: Fellow applicant
Organisation: Leiden University
Dr. G. Girard
Project function: Post Doc
Organisation: Leiden University
Contact information
Prof. dr. G. van Wezel
Universiteit Leiden
Faculteit der Wiskunde en Natuurwetenschappen
Gorlaeus Laboratorium
Postbus 9502
2300 RA LEIDEN
T: 071-523 39 17
E: g<dot>wezel<at>chem<dot>leidenuniv<dot>nl
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