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Project 10467: GENEXPAND: GENomics and EXpression of Peptide ANtibiotics and Derivatives




Project leader: Prof. dr. Gilles van Wezel

As the largest source of antibiotics, the filamentous soil bacteria of the family of actinomycetes are exceptional industrial microorganisms, and a major asset in combating multiple drug-resistant pathogens. The GenExpand project aims to identify antibiotics that have so far gone unnoticed, by combining full genome sequencing to identify hidden antibiotic clusters with the development of bioessays and chemical tweezers for the idenitification of specific classes of natural products. Within the project lantibiotics are a focal point. At the same time GenExpand will form a broad-impact benchmark for future antibiotic research by augmenting the available genome sequences of antibiotic-producing actinomycetes and by offering new technologies for compound identification


People involved

Prof. dr. G.P. van Wezel
Project function: Main applicant and project leader
Organisation: Leiden University

Prof. dr. A. van Belkum
Project function: Fellow applicant
Organisation: ERasmus MC Rotterdam

Dr. Y.H. Choi
Project function: Fellow applicant
Organisation: Leiden University

Dr. ing. M.O.M. Overhand
Project function: Fellow applicant
Organisation: Leiden University

Prof. dr. H.S. Overkleeft
Project function: Fellow applicant
Organisation: Leiden University

Prof. dr. R. Verpoorte
Project function: Fellow applicant
Organisation: Leiden University

Dr. E. Vijgenboom
Project function: Fellow applicant
Organisation: Leiden University

Dr. G. Girard
Project function: Post Doc
Organisation: Leiden University
 

Contact information

Prof. dr. G. van Wezel
Universiteit Leiden
Faculteit der Wiskunde en Natuurwetenschappen
Gorlaeus Laboratorium
Postbus 9502
2300 RA LEIDEN

T: 071-523 39 17
E: g<dot>wezel<at>chem<dot>leidenuniv<dot>nl